Indomethacin and perforated duodenal ulcer.

of a preceding pregnancy had any effect on the outcome of the subsequent pregnancy. A first, second, or third pregnancy was taken as the index pregnancy and the outcome of the subsequent pregnancy examined. The distribution of social classes in the sample was: class I, 12 %; class II, 16 %; class III, 48 %; class IV, 13 %; class V, 4 %; and 7% of patients were of unknown social class. The table shows the outcome of the pregnancy after the index pregnancy. There were 51 malformations after a normal pregnancy (2-4%) and 10 after a spontaneous abortion (23 %). Nine (18 °o) of the malformations after a normal pregnancy were of the central nervous system (CNS), as were four (40 %) of the malformations after a spontaneous abortion.